Discovery Informatics

Exclusive state of the art predictive computer modeling such as LeadHopping® can increase productivity by being better at spotting compounds best suited to your specific needs. Our unique software guides identification of novel, accessible, targeted compounds amenable to synthetic manipulation, allowing more effective deployment of resource and potentially reducing the need for screening.

Technologies include:

• ChemSpace® – A proprietary, multi-component environment used for the design, construction, management and searching of vast, chemically accessible virtual libraries
   
• ChemCore – a proprietary, comprehensive information management system that efficiently manages compounds through their lifecycle, enabling rapid, informed decision making regarding project direction.

Medicinal Chemistry

Through a highly inter-disciplinary mix of chemistry and biology based discovery research techniques, we focus on producing compounds specific to your needs and active against your biological targets. Our in-house expertise is supplemented with specialist technology partners so we can offer the design and synthesis of novel active candidates with disease modifying potential from hit finding to pre-clinical candidate selection.

Our multifunctional project teams integrate:

• Highly experienced medicinal chemists with diverse backgrounds and collective experience of over 90 targets
• High throughput synthetic chemists who pioneer innovative protocols to offer an efficient route for the full exploration of SAR over as few cycles as possible.
• In vitro ADME via our preferred partners, ADMETRx who offer improved decision making in lead selection and lead optimisation by providing high quality ADME profiling, data integration, analysis, and predictive modeling
  
• Pharmacokinetics
• Biochemistry functional assays
• Structural biology and protein expression

For further information please contact .